Reacción #52606

ord-0e408daf6e994476bc66956e12dee526

Ecuación de reacción

CCOC(=O)c1c(CCC(=O)O)c[nH]c1C
4-(2-Carboxyethyl)-3-ethoxycarbonyl-2-methylpyrrole
[K+].[OH-]
potassium hydroxide
→
Cc1[nH]cc(CCC(=O)O)c1C(=O)O
4-(2-carboxyethyl)-2-methyl-1H-pyrrole-3-carboxylic acid
Rendimiento 64.0%

Reactantes

CCOC(=O)c1c(CCC(=O)O)c[nH]c1C
4-(2-Carboxyethyl)-3-ethoxycarbonyl-2-methylpyrrole
[K+].[OH-]
potassium hydroxide

Reactivos

Ninguno

Disolventes

CCO
ethanol

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

4-(2-Carboxyethyl)-3-ethoxycarbonyl-2-methylpyrrole (Bulter, A. R., and George, S. D. (1993) Tetrahedron 49: 7017-7026) was hydrolyzed using potassium hydroxide (KOH) in ethanol (EtOH) to give 4-(2-carboxyethyl)-2-methyl-1H-pyrrole-3-carboxylic acid (64%).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06855730B2uspto-grants-2005_02