Reacción #5251

Ecuación de reacción

1-ethoxycarbonyl-4-hydroxy-4-(3,4-dichlorophenyl)piperidine

KOH

→

compound

Rendimiento 90.0%

4-Hydroxy-4-(3,4-dichlorophenyl)piperidine

Rendimiento 90.0%

Disolventes

nBuOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroevaporated
2. 2
   ConcentraciónThe reaction mixture is concentrated under reduced pressure
3. 3
   Extracciónextracted with ethyl acetate
4. 4
   LavadoThe organic layer is washed with water
5. 5
   Otrodried
6. 6
   Otroevaporated
7. 7
   OtroThe resulting crystalline residue is recrystallized from ethyl acetate

Procedimiento

A mixture of 64.2 g of 1-ethoxycarbonyl-4-hydroxy-4-(3,4-dichlorophenyl)piperidine (X-1) and a solution of 72.4 g of KOH in 700 ml of nBuOH is refluxed for 2 hours and evaporated. The reaction mixture is concentrated under reduced pressure and extracted with ethyl acetate. The organic layer is washed with water, dried and evaporated. The resulting crystalline residue is recrystallized from ethyl acetate to prepare 44.7 g (Yield: 90.0%) of the compound (II-1). mp. 144.5°-146.0° C.

Fuente