Reacción #52483

Ecuación de reacción

1-(4-bromophenyl)-cyclopropylamine

Intermediate 116

1-(4-bromophenyl)-cyclopropylamine

propionyl chloride

pyridine

→

title compound

Rendimiento 79.2%

N-[1-(4-bromophenyl)-cyclopropyl]-propionamide

Rendimiento 79.2%

Disolventes

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas quenched by the addition of H2O
2. 2
   Extracciónextracted with EtOAc
3. 3
   LavadoThe combined extracts were washed with 10% aqueous HCl, saturated aqueous NaHCO3, and saturated aqueous NaCl
4. 4
   Secadobefore being dried (MgSO4)
5. 5
   Concentraciónconcentrated under reduced pressure

Procedimiento

To a solution of 1-(4-bromophenyl)-cyclopropylamine (Intermediate 116, 84 mg, 0.4 mmol) in 4 mL CH2Cl2 at room temperature was added propionyl chloride (43.0 mg, 0.47 mmol) and pyridine (56.0 mg, 0.71 mmol). After stirring 17 hours at room temperature the reaction was quenched by the addition of H2O and extracted with EtOAc. The combined extracts were washed with 10% aqueous HCl, saturated aqueous NaHCO3, and saturated aqueous NaCl before being dried (MgSO4) and concentrated under reduced pressure. The title compound 85.0 mg (67%), was isolated by column chromatography (20-50% EtOAc—hexanes) as a colorless solid.

Fuente