Reacción #52480

Ecuación de reacción

HCl

KOH

ethylene glycol

1-(4-bromophenyl)-cyclopropanecarbonitrile

Intermediate 113

1-(4-bromophenyl)-cyclopropanecarbonitrile

→

title compound

Rendimiento 97.0%

1-(4-Bromophenyl)-cyclopropanecarboxylic acid

Rendimiento 97.0%

Disolventes

H2O

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooled to room temperature
2. 2
   Filtraciónthe solid was collected by filtration
3. 3
   Lavadowashed with H2O
4. 4
   OtroThe colorless solid was dried under reduced pressure

Procedimiento

To a solution of KOH (6.06 g, 0.11 mol) in 10 mL of H2O was added 40 mL of ethylene glycol and 1-(4-bromophenyl)-cyclopropanecarbonitrile (Intermediate 113, 10.0 g, 0.45 mol). This solution was heated to 135-140° C. for 4 h, cooled to room temperature, and then poured into a mixture of 100 mL ice and 10% aqueous HCl. The resulting mixture was allowed to stand overnight at 5° C., the solid was collected by filtration and washed with H2O. The colorless solid was dried under reduced pressure to give 10.6 g (97%) of the title compound.

Fuente