Reacción #5245

Ecuación de reacción

phosphorus oxychloride

2-aminothiazole

N-methylformanilide

→

crude product

Rendimiento 94.2%

N'-(2-THIAZOLYL)-N-METHYL-N-PHENYLFORMAMIDINE

Rendimiento 94.2%

Disolventes

toluene

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe temperature was maintained below 45° C. during this addition
2. 2
   workup.STIRRINGwith stirring
3. 3
   Otrowas quenched by dropwise addition into a mixture of 30% sodium hydroxide (325 g) and ice (300 g)
4. 4
   LavadoThe organic phase was washed with a mixture of water (100 g), sodium chloride (10 g), and sodium bicarbonate (7.5 g)
5. 5
   Secadothe resultant organic layer was dried over anhydrous magnesium sulfate
6. 6
   Filtraciónfiltered
7. 7
   Concentraciónconcentrated

Procedimiento

To a stirred suspension of N-methylformanilide (67.6 g; 0.50 mole), toluene (25 g) and 2-aminothiazole (2.0 g; 0.02 mole) was added phosphorus oxychloride (45.8 mL; 0.50 mole) over 15 minutes. The temperature was maintained below 45° C. during this addition. Stirring was continued for 10 minutes, after which time a hot solution of 2-aminothiazole (48.0 g; 0.48 mole) in toluene (250 g) was added at 60°-65° C. over 45 minutes. The reaction was allowed to cool to room temperature with stirring and was quenched by dropwise addition into a mixture of 30% sodium hydroxide (325 g) and ice (300 g). The organic phase was washed with a mixture of water (100 g), sodium chloride (10 g), and sodium bicarbonate (7.5 g), followed by a saturated solution of sodium chloride (125 g); the resultant organic layer was dried over anhydrous magnesium sulfate, filtered, and concentrated to yield 98.3 g of crude product. Vacuum distillation gave pure 1 (60.0 g; 55.3%) as a yellow oil: bp 177° C. @ 0.5 mm Hg. 1H-NMR (CDCl3) 8.72 (s, 1H), 7.4-6.9 (m, 7H), 3.50 (S, 3H); IR(neat) 3075, 2950, 1615, 1580, 1490, 1345, 1310, 1120; MS (m/e) 217 (M+, base).

Fuente