Reacción #524394

Ecuación de reacción

sodium iodide

2-Cyclohexylethyl bromide

4-benzamidopiperidine

diisopropylamine

→

1-[2-(Cyclohexyl)ethyl]-4-benzamidopiperidine

Disolventes

dimethylformamide

water

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooled
2. 2
   Extracciónextracted with methylene chloride
3. 3
   LavadoThe washed
4. 4
   Otrodried extracts
5. 5
   Otrowere evaporated
6. 6
   Otrothe solid residue was recrystallised from ethanol
7. 7
   Otroto give the product (1.25 g.), m.p. 174°-5° C. (Found: C, 76.4; H, 9.5; N, 8.9 C20H30N2O requires C, 76.4; H, 9.6; N, 8.9%)

Procedimiento

2-Cyclohexylethyl bromide (1.9 g.) in dimethylformamide (10 ml.) was added to 4-benzamidopiperidine (2.2g.), diisopropylamine (4 ml.) and a trace of sodium iodide in dimethylformamide (10 ml). The mixture was heated at 70° C. for 16 hours, cooled, poured into water, and extracted with methylene chloride. The washed and dried extracts were evaporated and the solid residue was recrystallised from ethanol to give the product (1.25 g.), m.p. 174°-5° C. (Found: C, 76.4; H, 9.5; N, 8.9 C20H30N2O requires C, 76.4; H, 9.6; N, 8.9%).

Fuente