Reacción #524332

Ecuación de reacción

6-chloro-4-fluoro-3-sulfamoylbenzoic acid

N-butylpiperazine

→

4-(4-n-butylpiperazine-1-yl)-6-chloro-3-sulfamoylbenzoic acid

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroa small amount of amorphous precipitate formed
2. 2
   Otrowas separated
3. 3
   Filtraciónthe crystalline precipitate was suction-filtered
4. 4
   Otrowas recrystallized from a mixture of ethanol and water

Procedimiento

126 Grams of 6-chloro-4-fluoro-3-sulfamoylbenzoic acid (0.5 mole) were stirred with 0.2 l of N-butylpiperazine for 2 hours at 110° C. Subsequently the reaction solution was poured into 2 l of water, a small amount of amorphous precipitate formed was separated, and the filtrate was adjusted to a pH of 7.5 with 2N HCl. After having stood overnight at room temperature, the crystalline precipitate was suction-filtered and was recrystallized from a mixture of ethanol and water.

Fuente