Reacción #52407

Ecuación de reacción

triethyl amine

Intermediate 51

6-bromo-1-cyclopropyl-4,4-dimethyl-1,2,3,4-tetrahydro quinoline

(trimethylsilyl)acetylene

6-bromo-1-cyclopropyl-4,4-dimethyl-1,2,3,4-tetrahydro quinoline

→

title compound

1-Cyclopropyl-6-trimethylsilanylethynyl-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline

Disolventes

tetrahydrofuran

Condiciones de reacción

Procedimiento

Following general procedure D and using 6-bromo-1-cyclopropyl-4,4-dimethyl-1,2,3,4-tetrahydro quinoline (Intermediate 51, 0.8 g, 2.86 mmol), (trimethylsilyl)acetylene (5 mL, 35 mmol), triethyl amine (10 mL), anhydrous tetrahydrofuran, copper(I)iodide (0.080 g, 0.42 mmol) and dichlorobis(triphenylphosphine)palladium(II) (0.240 g, 0.34 mmol), the title compound was obtained as an oil (0.67 g, 79%).

Fuente