Reacción #5236

Ecuación de reacción

compound

1-(Cyclopropylmethyl)-4-(4'-Fluorophenoxymethyl)piperidine

4-fluorophenylmagnesium bromide

tetrahydrofuran

→

title compound

1-(Cyclopropylmethyl)-4-(2',2'-bis (4"-Fluorophenyl)-2-hydroxyethyl)piperidine

Condiciones de reacción

Procedimiento

Following the procedure described for Example 547, the compound of Example 429 (1.0 g, 3.6 mmol) was reacted a solution of 4-fluorophenylmagnesium bromide in tetrahydrofuran (1.0M, 9 mL, 9 mmol) to give the title compound, a solid (1.1 g): mp 119°-121° C.; Anal.: Calcd for C23H27F2NO.0.5H2O: C, 72.60, H, 7.41, N, 3.68, F, 9.99; Found: C, 72.89, 72.84, H, 7.14, 7.21, N, 3.29, 3.24, F, 9.82, 9.67.

Fuente