Reacción #52308

Ecuación de reacción

Sodium thiomethoxide

3,5-dibromopyridine

→

title compound

Rendimiento 89.0%

3-Bromo-5-methylsulfanyl-pyridine

Rendimiento 89.0%

Disolventes

ethyl acetate

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed several times with brine
2. 2
   SecadoThe extracts were dried over magnesium sulfate
3. 3
   Otrothe solvent was removed under reduced pressure
4. 4
   OtroThe crude material was chromatographed on silica (10% ethyl acetate/hexanes)

Procedimiento

Sodium thiomethoxide (1.6 g, 23 mmol) was added to a solution of 3,5-dibromopyridine (5 g, 21 mmol) in DMF (25 mL). After stirring overnight at room temperature, the reaction mixture was diluted with ethyl acetate and washed several times with brine. The extracts were dried over magnesium sulfate and the solvent was removed under reduced pressure. The crude material was chromatographed on silica (10% ethyl acetate/hexanes) to give the title compound (3.8 g, 89% yield) as a clear oil.

Fuente