Reacción #52231

ord-7908a31fbbb64d2282804f5d3fcaa166

Ecuación de reacción

Cc1ccc(C(=O)O)cc1O
3-hydroxy-4-methylbenzoic acid
O=S(=O)(O)O
sulfuric acid
CC(=O)OC(C)=O
acetic anhydride
→
CC(=O)Oc1cc(C(=O)O)ccc1C
title compound
Rendimiento 30.0%
CC(=O)Oc1cc(C(=O)O)ccc1C
3-Acetoxy-4-methylbenzoic acid
Rendimiento 30.0%

Reactantes

Cc1ccc(C(=O)O)cc1O
3-hydroxy-4-methylbenzoic acid
O=S(=O)(O)O
sulfuric acid
CC(=O)OC(C)=O
acetic anhydride

Reactivos

Ninguno

Disolventes

O
water

Condiciones de reacción

Temperatura
70°CELSIUS
Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Temperaturacooled
  2. 2
    FiltraciónThe resulting solid was collected by filtration

Procedimiento

A solution of 3-hydroxy-4-methylbenzoic acid (3.0 g, 19.7 mmol) in acetic anhydride (5.6 mL) was treated with sulfuric acid (0.03 mL), heated to 70° C., cooled and diluted with water. The resulting solid was collected by filtration yielding 1.14 g (30%) of the title compound, which was used without further purification.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06855715B1uspto-grants-2005_02