Reacción #522238

Ecuación de reacción

benzene

benzene

dichloroacetyl chloride

2,2,4-trimethyl-5-phenyl oxazolidine

→

title compound

2,2,4-trimethyl-3-dichloroacetyl-5-phenyl oxazolidine

Disolventes

triethylamine

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrostripped at room temperature, while 4.4 g
2. 2
   Lavadothe mixture was washed with water
3. 3
   Otroseparated
4. 4
   Secadodried over magnesium sulfate
5. 5
   OtroThe product which crystallized
6. 6
   Extracciónwas extracted with ether
7. 7
   Otroprecipitated with pentane
8. 8
   OtroThere was obtained 3.9 g

Procedimiento

Twenty-three (23) ml. of a benzene solution containing 5.7 g. of 2,2,4-trimethyl-5-phenyl oxazolidine was mixed with 25 ml. of benzene and 3.1 g. of triethylamine and stripped at room temperature, while 4.4 g. of dichloroacetyl chloride was added dropwise. After standing for about 30 minutes, the mixture was washed with water, separated, dried over magnesium sulfate and stripped under vacuum. The product which crystallized was extracted with ether and precipitated with pentane. There was obtained 3.9 g. of a solid, the title compound, m.p. 126° C.

Fuente