Reacción #520228

Ecuación de reacción

compound 12

(R)-(−)-1-Methyheptyl 4-Benzyloxy-3-fluorobenzoate

→

(R)-(−)-1-Methylheptyl 4-Hydroxy-3-fluorobenzoate

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solution was evacuated
2. 2
   workup.WAITleft
3. 3
   FiltraciónThe catalyst was filtered off
4. 4
   Otrothe solvent removed in vacuo
5. 5
   Otroto yield a yellow oil which
6. 6
   Otrowas purified by column chromatography (dichloromethane) on silica
7. 7
   Otroto yield the pure colourless oil
8. 8
   Otroat 25° C.

Procedimiento

10% Palladium on charcoal (0.3 g), was added to a solution of compound 12 (10.0 g, 28 mmol) in ethyl acetate (300 ml). The solution was evacuated and left stirring with hydrogen at atmospheric pressure for 24 h. The catalyst was filtered off and the solvent removed in vacuo to yield a yellow oil which was purified by column chromatography (dichloromethane) on silica to yield the pure colourless oil. Yield 5.8 g (77%). [α]D=−33.7° at 25° C.

Fuente