Reacción #51970

Ecuación de reacción

4-acetamidoacetophenone

bromine

→

title compound

Rendimiento 62.5%

N-[4-(2-bromoacetyl)phenyl]acetamide

Rendimiento 62.5%

Disolventes

1,4-dioxane diethyl ether

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe solid was collected by filtration
2. 2
   Lavadowashed with diethyl ether
3. 3
   Otrodried under high vacuum

Procedimiento

To a suspension of 4-acetamidoacetophenone (Lancaster, 5.32 g, 0.03 mol) in 1,4-dioxane/diethyl ether (100 mL, 1:2, v/v) was added bromine (1.53 mL, 0.03 mol) via a syringe. The reaction mixture was stirred at room temperature for 4 hours until the color of the mixture was changed from brown to white. The solid was collected by filtration, washed with diethyl ether, and dried under high vacuum to give the title compound as a white solid (4.8 g).

Fuente