Reacción #519339

Ecuación de reacción

3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole

water

formamide

→

pure product

Rendimiento 80.0%

4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine

Rendimiento 80.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONadded
2. 2
   Otrothe solid collected
3. 3
   Lavadowashed well with water
4. 4
   Secadomethanol and dried in air

Procedimiento

3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole (Intermediate AB) (29.5 g) was suspended in 300 mL formamide and heated under nitrogen at 180° C. for 4 hours, cooled to 30 C, 300 mL water added and the solid collected, washed well with water then methanol and dried in air giving 24.6 g pure product (80%) of 4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine m.p. 267-269° C. as pale brown-grey solid. Calculated for C17H13N5O C 67.3H 4.3 N 23.1 Found C 67.0H 4.4 N 23.1.

Fuente