Reacción #51762

Ecuación de reacción

bromine

5-isopropyl-2-nitro-phenylamine

sodium thiocyanate

sodium bromide

→

title compound

5-Isopropyl-2-nitro-4-thiocyanato-phenylamine

Disolventes

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe crude reaction mixture
2. 2
   Otrowas purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents)

Procedimiento

The title compound was prepared according to General Method 13 using 5-isopropyl-2-nitro-phenylamine (prepared in Example PP-1; 5.4 g, 30 mmol), sodium thiocyanate (14.6 g, 180 mmol), sodium bromide (3.7 g, 35.99 mmol), bromine (5.75 g, 36.0 mmol), and MeOH (100 mL). The crude reaction mixture was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents). MS(APCI): 238 (M+H).

Fuente