Reacción #517214

Ecuación de reacción

benzoic acid

1,2-phenylenediamine

trifluoroacetic acid

→

N-(2-aminophenyl)benzamide

Rendimiento 59.8%

Disolventes

dimethyl sulfoxide

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwere added dropwise at room temperature
2. 2
   OtroAfter reaction
3. 3
   workup.WAIThad been further carried out at room temperature for 15 hours

Procedimiento

1.62 g (10 mmole) of N,N′-carbonyldiimidazole were added to a dimethyl sulfoxide (10 ml) solution including 1.12 g (10 mmole) of benzoic acid, followed by stirring at room temperature for 1 hour. After the addition of 2.16 g (20 mmole, 2 equivalents) of 1,2-phenylenediamine, 1.9 ml of trifluoroacetic acid were added dropwise at room temperature. After reaction had been further carried out at room temperature for 15 hours, a post-treatment was performed in the same manner as in Example 6 to obtain 1.27 g (yield: 59%) of N-(2-aminophenyl)benzamide.

Fuente