Reacción #51658

Ecuación de reacción

(7-Methoxy-1H-indol-3-yl)-dimethyl-sulfonium chloride

→

7-methoxy-3-methylsulfanyl-1H-indole

Rendimiento 87.5%

Disolventes

DMSO

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroplaced under reduced pressure (house vacuum, ca. 20-50 torr) in a round-bottom flask
2. 2
   OtroThe flask was placed on a steam bath
3. 3
   Temperaturaheated until the bubbling
4. 4
   Temperaturathe reaction mixture was cooled
5. 5
   Otropartitioned between ether and water
6. 6
   OtroThe organic layer was dried
7. 7
   Filtraciónfiltered
8. 8
   Otroevaporated to dryness

Procedimiento

(7-Methoxy-1H-indol-3-yl)-dimethyl-sulfonium chloride (0.742 g) prepared in the manner described in Step 1 above was dissolved in DMSO (3 ml) and placed under reduced pressure (house vacuum, ca. 20-50 torr) in a round-bottom flask. The flask was placed on a steam bath and heated until the bubbling stopped. When no more starting material was present, the reaction mixture was cooled and partitioned between ether and water. The organic layer was dried and filtered and then evaporated to dryness to afford 7-methoxy-3-methylsulfanyl-1H-indole (0.514 g, 87.5%).

Fuente