Reacción #51637

Ecuación de reacción

acetic anhydride

ketal

17,17-Ethylenedioxy-2-methoxyestra-1,3,5(10)-trien-3-ol

pyridine

→

3-acetate

Rendimiento 96.1%

17,17-Ethylenedioxy-2-methoxyestra-1,3,5(10)-trien-3-ol Acetate

Rendimiento 96.1%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrosolvents removed in vacuo
2. 2
   Otrothe residue obtained
3. 3
   Otrocrystallized from methanol

Procedimiento

Under nitrogen, acetic anhydride (25 mL, 265 mmol) was added to a solution of the ketal (11) (4.5 g, 13.06 mmol) in dry pyridine (25 mL, 310 mmol). The reaction was stirred overnight at room temperature in the dark. After that time, methanol (50 mL) was added and solvents removed in vacuo. The treatment with methanol was repeated and the residue obtained crystallized from methanol to give the pure 3-acetate (12) (4.85 g, 96%).

Fuente