Reacción #51634

Ecuación de reacción

bromo(4-nitrophenyl)acetaldehyde

potassium thiocyanate

cyclohexylamine

→

desired compound

N-cyclohexyl-5-(4-nitrophenyl)-1,3-thiazol-2-amine

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture is heated
2. 2
   Temperaturaunder reflux until completion of the reaction (5-12 hours)
3. 3
   Filtraciónis filtered off
4. 4
   Lavadowashed with water
5. 5
   OtroThe crude material is purified by usual silica gel chromatography

Procedimiento

A solution of bromo(4-nitrophenyl)acetaldehyde and potassium thiocyanate (1.2 equivalents) in methanol is stirred at room temperature for 1 hour. The cyclohexylamine (1,05 equivalents) is added drop-wise and the mixture is heated under reflux until completion of the reaction (5-12 hours). After cooling to 0° C. the precipitate is filtered off and washed with water. The crude material is purified by usual silica gel chromatography to give the desired compound.

Fuente