Reacción #51602

Ecuación de reacción

5B

Methyl (3-hydroxy-5trifluoromethylthien-2-yl)-carboxylate

methanol

sodium hydroxide

→

acid

Rendimiento 65.0%

(3-Hydroxy-5-trifluoromethylthien-2-yl)-carboxylic acid

Rendimiento 65.0%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture was heated
2. 2
   Temperaturaat reflux for 3 hours
3. 3
   Concentraciónconcentrated in vacuo
4. 4
   TemperaturaThe concentrate was cooled to 5° C.
5. 5
   FiltraciónThe solid was collected by filtration
6. 6
   Lavadowashed with water
7. 7
   Otrodried in vacuo at 35-40° C.

Procedimiento

A mixture of 5B (2.38 g) and methanol (20 ml) was added to a stirred solution of sodium hydroxide (1.68 g) in water (20 ml). The reaction mixture was heated at reflux for 3 hours. The reaction mixture was cooled to room temperature and concentrated in vacuo. The concentrate was cooled to 5° C. and acidified with concentrated HCl (3.5 ml). The resulting suspension was stirred at 5° C. for 30 minutes. The solid was collected by filtration, washed with water, then dried in vacuo at 35-40° C. to give the free acid (1.45 g, 65%).

Fuente