Reacción #51462

Ecuación de reacción

piperonylamine

Isobutyl chloroformate

N-Boc sarcosine

N-methylmorpholine

→

N-Boc sarcosine piperonyl amide

Rendimiento 95.0%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.WAITAfter thirty minutes
2. 2
   Otroall volatiles were removed under reduced pressure

Procedimiento

Isobutyl chloroformate (226 μL, 1.73 mmol) was added to a solution of N-Boc sarcosine (1.73 mmol) and N-methylmorpholine (192 μL, 1.73 mmol) in THF. After two minutes, piperonylamine (216 mL, 1.73 mmol) was added and the mixture allowed to warm to room temperature. After thirty minutes, the reaction mixture was passed through a bed of Celite and all volatiles were removed under reduced pressure to yield N-Boc sarcosine piperonyl amide (531 mg, 95%) as a white solid. 1H NMR: (CDCl3) δ2.41 (s,3), 3.28 (s,2), 4.39 (d,2), 5.95 (s,2), 6.80 (m,3), 7.43 (bs,1), 9.04 (bs,1).

Fuente