Reacción #5146

Ecuación de reacción

methacryloyl chloride

2-bromo-4-2-hydroxyethoxymethylthiophene

pyridine

acetonitrile

water

→

2-bromo-4-thienyl-methoxyethyl methacrylate

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGAfter stirring the mixture for one hour
2. 2
   ExtracciónThe ethyl acetate layer was extracted
3. 3
   Concentraciónconcentrated
4. 4
   Otropurified by column chromatography

Procedimiento

While stirring a mixture of 0.1 mol of 2-bromo-4-2-hydroxyethoxymethylthiophene, 0.1 mol of pyridine, and 100 ml of acetonitrile at a temperature of lower than 10° C., 0.1 mol of methacryloyl chloride was added dropwise to the mixture over a period of 30 minutes. After stirring the mixture for one hour, 200 ml of ethyl acetate and 200 ml of water were added to the mixture. The ethyl acetate layer was extracted, concentrated, and purified by column chromatography to provide 22.1 g of 2-bromo-4-thienyl-methoxyethyl methacrylate (5-A).

Fuente