Reacción #514362

Ecuación de reacción

1-Butoxycarbonylamino-4-(1-iminoethylamino)but-2-yne

HCl dioxane

→

1-amino-4-(1-iminoethylamino)but-2-yne

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter this time the mother liquor was decanted off
2. 2
   Otroto remove residual solvent
3. 3
   OtroThe resulting material was triturated with dry diethyl ether (×2)
4. 4
   Filtraciónfiltered off
5. 5
   Lavadowashed with more dry diethyl ether
6. 6
   OtroThe yellow solid was finally dried in a drying pistol

Procedimiento

1-Butoxycarbonylamino-4-(1-iminoethylamino)but-2-yne (0.332 g) was deprotected by treatment with 4 N HCl/dioxane (3 ml) at 0° C. and stirring at 0° C. for 1h then at room temperature for 1h. After this time the mother liquor was decanted off and the sticky residue subjected to an oil pump vacuum to remove residual solvent. The resulting material was triturated with dry diethyl ether (×2), filtered off and washed with more dry diethyl ether. The yellow solid was finally dried in a drying pistol to yield 1-amino-4-(1-iminoethylamino)but-2-yne 2.5hydrochloride (0.184 g), Mpt 182°-185° C.(dec), FAB M.S. M+1+126.

Fuente