Reacción #51349

ord-1fe96754c66a433d836a5929de7f6a46

Ecuación de reacción

O=C(O)Cc1cccc2ccccc12
1-naphthylacetic acid
CC(C)COC(=O)[C@H](C)N.Cl
L-alanine iso-butyl ester hydrochloride
→
CC(C)COC(=O)[C@H](C)NC(=O)Cc1cccc2ccccc12
title compound
CC(C)COC(=O)[C@H](C)NC(=O)Cc1cccc2ccccc12
N-[(1-naphthyl)acetyl]-L-alanine iso-butyl ester

Reactantes

O=C(O)Cc1cccc2ccccc12
1-naphthylacetic acid
CC(C)COC(=O)[C@H](C)N.Cl
L-alanine iso-butyl ester hydrochloride

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe reaction was monitored by tlc on silica gel and purification
  2. 2
    Extracciónwas by extraction with Et2O

Procedimiento

Following General Procedure BB and using 1-naphthylacetic acid (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as a solid having a melting point of 69°-73° C. The reaction was monitored by tlc on silica gel and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06849650B2uspto-grants-2005_02