Reacción #51330

ord-e4defc8176564c78905f4f164eeb6e1d

Ecuación de reacción

Cc1ccc2cc(N)ccc2n1
6-amino-2-methylquinoline
CC(=O)C(=O)OCC(C)C
iso-butyl pyruvate
→
Cc1ccc2cc(N[C@@H](C)C(=O)OCC(C)C)ccc2n1
title compound
Cc1ccc2cc(N[C@@H](C)C(=O)OCC(C)C)ccc2n1
N-(2-methylquinolin-6-yl)alanine iso-butyl ester

Reactantes

Cc1ccc2cc(N)ccc2n1
6-amino-2-methylquinoline
CC(=O)C(=O)OCC(C)C
iso-butyl pyruvate

Reactivos

Ninguno

Disolventes

—
EtOAc hexanes

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroPurification

Procedimiento

Following General Procedure AA above and using 6-amino-2-methylquinoline (Lancaster) and iso-butyl pyruvate (prepared by following General Procedure AO above), the title compound was prepared. The reaction was monitored by silica gel tlc (Rf=0.44 in 50% EtOAc/hexanes). Purification was by flash chromatography (silica gel using 50% EtOAc/hexanes as the eluant).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06849650B2uspto-grants-2005_02