Reacción #51321

ord-72ce8be3f194447cb3b1c4857406577e

Ecuación de reacción

Nc1cc(Cl)cc(Cl)c1
3,5-dichloroaniline
CC(=O)C(=O)OCC(C)C
iso-butyl pyruvate
→
CC(C)COC(=O)[C@H](C)Nc1cc(Cl)cc(Cl)c1
title compound
CC(C)COC(=O)[C@H](C)Nc1cc(Cl)cc(Cl)c1
N-(3,5-dichlorophenyl)alanine iso-butyl ester

Reactantes

Nc1cc(Cl)cc(Cl)c1
3,5-dichloroaniline
CC(=O)C(=O)OCC(C)C
iso-butyl pyruvate

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe reaction was monitored by tlc on silica gel (Rf=0.4 in 25% EtOAc/hexanes) and purification

Procedimiento

Following General Procedure AA above and using 3,5-dichloroaniline (Aldrich) and iso-butyl pyruvate (prepared by following General Procedure AO above), the title compound was prepared as an oil. The reaction was monitored by tlc on silica gel (Rf=0.4 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06849650B2uspto-grants-2005_02