Reacción #51315

ord-d19ed8de5f414a199d61412d9e08cb85

Ecuación de reacción

Nc1ccc(Cl)c(Cl)c1
3,4-dichloroaniline
CC(C)COC(=O)C(=O)CC(C)C
iso-butyl 4-methyl-2-oxopentanoate
→
CC(C)COC(=O)[C@H](CC(C)C)Nc1ccc(Cl)c(Cl)c1
title compound
CC(C)COC(=O)[C@H](CC(C)C)Nc1ccc(Cl)c(Cl)c1
N-(3,4-dichlorophenyl)leucine iso-butyl ester

Reactantes

Nc1ccc(Cl)c(Cl)c1
3,4-dichloroaniline
CC(C)COC(=O)C(=O)CC(C)C
iso-butyl 4-methyl-2-oxopentanoate

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe reaction was monitored by tlc on silica gel (Rf=0.6 in 25% EtOAc/hexanes) and purification

Procedimiento

Following General Procedure AA above and using 3,4-dichloroaniline (Aldrich) and iso-butyl 4-methyl-2-oxopentanoate (prepared by following General Procedure AO above using 4-methyl-2-oxovaleric acid (Fluka) and iso-butanol), the title compound was prepared as an oil. The reaction was monitored by tlc on silica gel (Rf=0.6 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06849650B2uspto-grants-2005_02