Reacción #51299

Ecuación de reacción

iso-butanol

pyridine

2-bromopropionyl bromide

→

title compound

Iso-butyl 2-bromopropionate

Disolventes

diethyl ether

diethyl ether

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with 1N HCl, water, aqueous NaHCO3, brine
2. 2
   Secadodried over magnesium sulfate or sodium sulfate
3. 3
   OtroRemoval of the solvents at reduced pressure

Procedimiento

To a mixture of iso-butanol and 1.0 equivalent of pyridine in dry diethyl ether was added dropwise 1.3 equivalents of 2-bromopropionyl bromide at 0° C. After stirring at room temperature for 16 hours, the reaction was diluted with diethyl ether, washed with 1N HCl, water, aqueous NaHCO3, brine and dried over magnesium sulfate or sodium sulfate. Removal of the solvents at reduced pressure gave the title compound as a clear oil.

Fuente