Reacción #51258

Ecuación de reacción

product

8-amino-1-{4-[(aminothio)peroxy]phenyl}-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide

NMP

→

title compound

Rendimiento 90.5%

8-amino-1-{4-[(aminothio)peroxy]phenyl}-1H-benzo[g]indazole-3-carboxamide

Rendimiento 90.5%

Disolventes

cumene

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux for 16 h
2. 2
   FiltraciónThe mixture was then filtered
3. 3
   Concentraciónconcentrated
4. 4
   workup.ADDITIONThe residue was diluted with methanol (10 mL)
5. 5
   workup.ADDITIONadded to water, after 1 h the resulting precipitate
6. 6
   Filtraciónwas collected by filtration
7. 7
   Otrodried

Procedimiento

The product of Example 4b (1 g) and 5% Pd/C (300 mg) suspended in cumene (50 mL) and NMP (5 mL) was heated at reflux for 16 h. The mixture was then filtered and concentrated. The residue was diluted with methanol (10 mL) and added to water, after 1 h the resulting precipitate was collected by filtration and dried to yield the title compound (0.9 g).

Fuente