Reacción #51163

Ecuación de reacción

2-chloro-6-methoxy-3-nitropyridine

sodium thiomethoxide

→

6-methoxy-2-methylthio-3-nitropyridine

Rendimiento 60.5%

Disolventes

methanol

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawhile being cooled with ice
2. 2
   Filtraciónthe precipitated crystal was filtered

Procedimiento

A methanol (100 ml) solution of 2-chloro-6-methoxy-3-nitropyridine (2.0 g, 10.4 mmol) was added dropwise to a methanol (20 ml) solution of sodium thiomethoxide (805 mg, 10.9 mmol) while being cooled with ice, and the temperature thereof was raised to the room temperature and the mixed solution was stirred for 17 hours and the precipitated crystal was filtered to obtain 1.26 g (yield 59%) of 6-methoxy-2-methylthio-3-nitropyridine as a yellow powdery crystal.

Fuente