Reacción #510460

Ecuación de reacción

4′-trifluoromethylbiphenyl-2-carboxylic acid (2-dimethylcarbamoyl-4-formylphenyl)amide

N-methylglycine methyl ester hydrochloride

sodium triacetoxyborohydride

→

title compound

Rendimiento 73.1%

({3-Dimethylcarbamoyl-4-[(4′-trifluoromethylbiphenyl-2-carbonyl)amino]benzyl}methylamino)acetic acid methyl ester

Rendimiento 73.1%

Disolventes

dichloromethane

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed successively with saturated aqueous sodium bicarbonate and saturated brine
2. 2
   Secadodried over anhydrous sodium sulfate
3. 3
   Concentraciónconcentrated in vacuo
4. 4
   OtroThe residue was purified by column chromatography on silica gel (chloroform

Procedimiento

To a solution of 4′-trifluoromethylbiphenyl-2-carboxylic acid (2-dimethylcarbamoyl-4-formylphenyl)amide (137 mg) and N-methylglycine methyl ester hydrochloride (45 mg) in dichloromethane (2 mL) was added sodium triacetoxyborohydride (97 mg). The mixture was stirred at room temperature for 4 hours, diluted with ethyl acetate, washed successively with saturated aqueous sodium bicarbonate and saturated brine, dried over anhydrous sodium sulfate, and concentrated in vacuo. The residue was purified by column chromatography on silica gel (chloroform:methanol=100:1, v/v) to give the title compound (120 mg).

Fuente