Reacción #5095

Ecuación de reacción

2,3-dihydro-2,4,6-trimethyl-7-methoxy-2-benzyl-1H-inden-1-one

sodium iodide

aluminium chloride

→

2,3-dihydro-2,4,6-trimethyl-7-hydroxy-2-benzyl-1H-indene-1-one

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThen the solvent was removed by evaporation under a reduced pressure
2. 2
   Otrothe residue thus obtained
3. 3
   Extracciónwas extracted with ethyl acetate
4. 4
   LavadoThe extract was washed with an aqueous solution saturated with sodium chloride
5. 5
   Otroan aqueous solution of sodium thiosulfate and an aqueous solution saturated with sodium chloride in this order, and the insoluble matters were removed by filtration
6. 6
   OtroThe solvent was removed by evaporation
7. 7
   Otrothe residue thus obtained
8. 8
   Otrowas recrystallized from n-hexane

Procedimiento

23.0 Grams of 2,3-dihydro-2,4,6-trimethyl-7-methoxy-2-benzyl-1H-inden-1-one and 25.8 g of sodium iodide were dissolved in 90 ml of acetonitrile. To this solution was added 22.9 g of aluminium chloride at room temperature and stirred for 1 hour. Then the solvent was removed by evaporation under a reduced pressure, and the residue thus obtained was extracted with ethyl acetate. The extract was washed with an aqueous solution saturated with sodium chloride, an aqueous solution of sodium thiosulfate and an aqueous solution saturated with sodium chloride in this order, and the insoluble matters were removed by filtration. The solvent was removed by evaporation and the residue thus obtained was recrystallized from n-hexane to obtain 19.7 of 2,3-dihydro-2,4,6-trimethyl-7-hydroxy-2-benzyl-1H-indene-1-one. Colorless prism-like crystals.

Fuente