Reacción #5088

Ecuación de reacción

sulfuric acid

2,4-dimethyl-6-(2-phenylacryloyl)phenol

→

2,3-dihydro-4,6-dimethyl-2-phenyl-7-hydroxy-1H-inden-1-one

Rendimiento 70.3%

Disolventes

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe whole mixture was stirred at room temperature for 1 hour
2. 2
   Extracciónextracted with 200 ml of methylene chloride
3. 3
   LavadoThe extract was washed with water
4. 4
   Secadodried with anhydrous magnesium sulfate
5. 5
   Concentraciónwas concentrated under a reduced pressure
6. 6
   Otroto obtain the residue
7. 7
   OtroThe residue was recrystallized from ethanol

Procedimiento

Into 15 ml of concentrated sulfuric acid, under ice-cooled condition with stirring, 3.0 g of 2,4-dimethyl-6-(2-phenylacryloyl)phenol was added gradually, then the whole mixture was stirred at room temperature for 1 hour. The reaction mixture was poured in 100 g of ice and extracted with 200 ml of methylene chloride. The extract was washed with water and dried with anhydrous magnesium sulfate, then was concentrated under a reduced pressure to obtain the residue. The residue was recrystallized from ethanol to obtain 2.11 g of 2,3-dihydro-4,6-dimethyl-2-phenyl-7-hydroxy-1H-inden-1-one.

Fuente