Reacción #5086

Ecuación de reacción

4-(3-chlorophenyl)-piperazine

sodium hydride

epichlorohydrin

→

4-(3-chlorophenyl)-1-(2,3-epoxypropyl)piperazine

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe reaction mixture was extracted with 100 ml of ethyl acetate
2. 2
   Lavadothe extract was washed 5 times with 100 ml of water
3. 3
   Secadodried with anhydrous magnesium sulfate
4. 4
   OtroThe solvent was removed by evaporation
5. 5
   Otroto obtain the residue which
6. 6
   Otrowas purified by means of a silica gel column chromatography (eluent: ethyl acetate: n-hexane=1:1)

Procedimiento

To a mixture of 1.50 g of 4-(3-chlorophenyl)-piperazine and 0.31 g of sodium hydride was added 2.4 ml of epichlorohydrin and the reaction mixture as stirred at room temperature for 30 minutes. After the reaction was completed, the reaction mixture was extracted with 100 ml of ethyl acetate, and the extract was washed 5 times with 100 ml of water, then dried with anhydrous magnesium sulfate. The solvent was removed by evaporation to obtain the residue which was purified by means of a silica gel column chromatography (eluent: ethyl acetate: n-hexane=1:1) to obtain 1.66 g of 4-(3-chlorophenyl)-1-(2,3-epoxypropyl)piperazine as in the form of an oily substance.

Fuente