Reacción #50816

Ecuación de reacción

sodium bicarbonate

5-(p-carboxyphenyl)imidazo[1,5-a]pyridine

oxalyl chloride

tert-butylamine

→

title compound

5-(p-tert-Butylaminocarbonylphenyl)imidazo[1,5-a]pyridine

Disolventes

methylene chloride

N,N-dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGStirring
2. 2
   OtroThe organic layer is separated
3. 3
   Secadodried over sodium sulfate
4. 4
   Otroevaporated

Procedimiento

To a slurry of 0.4 g of 5-(p-carboxyphenyl)imidazo[1,5-a]pyridine in 40 ml of methylene chloride under nitrogen at room temperature, is added 30 μl of N,N-dimethylformamide followed by 0.16 ml of oxalyl chloride. The reaction mixture is stirred until gas evolution is complete and 0.46 ml of tert-butylamine is added dropwise. Stirring is discontinued after 90 min and 10 ml of saturated sodium bicarbonate solution is added. The organic layer is separated, dried over sodium sulfate and evaporated to yield the title compound, m.p. 128°-131°.

Fuente