Reacción #50645

Ecuación de reacción

4-chloro-3-trifluoromethylcinnamonitrile

hydroxylamine hydrochloride

sodium carbonate

→

(E)-4-chloro-3-trifluoromethylcinnamamide oxime

Rendimiento 40.1%

Disolventes

water

water

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture is heated
2. 2
   Temperaturaat reflux temperature until the reaction
3. 3
   Otro(24 hours)
4. 4
   Filtraciónis filtered off with suction
5. 5
   Lavadowashed with a little water
6. 6
   Otrodried

Procedimiento

12.1 g (0.05 mol) of 4-chloro-3-trifluoromethylcinnamonitrile are added to a solution consisting of 7.2 g (0.10 mol) of hydroxylamine hydrochloride and 7.3 g (0.10 mol) of sodium carbonate in 100 ml of water and 100 ml of ethanol. The mixture is heated at reflux temperature until the reaction is complete (24 hours) and the whole batch is subsequently stirred into 250 ml of water. The solid material which separates off during this process is filtered off with suction, washed with a little water and dried. 5.3 g (39.3% of theory) of (E)-4-chloro-3-trifluoromethylcinnamamide oxime are obtained.

Fuente