Reacción #50630

Ecuación de reacción

8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one

1-(4-nitrophenyl)piperazine

Fumarate

→

2,3-dihydro-7-methoxy-8-{3-[4-(4-nitrophenyl)-1-piperazinyl]propoxy}cyclopenta[c][1]benzopyran-4(1H)-one

Rendimiento 43.0%

Disolventes

acetone

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroMethod B (60 h at 50° C.)

Procedimiento

Method B (60 h at 50° C.); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 1-(4-nitrophenyl)piperazine; yield 43%; fusion point 226°-228° C. (decomposes; from acetone). Fumarate: method E; yield 92%; fusion point 216° C. (decomposes; from acetone).

Fuente