Reacción #50629

Ecuación de reacción

Fumarate

potassium carbonate

8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one

1-(2-hydroxyphenyl)piperazine dihydrobromide

→

2,3-dihydro-8-{3-[4-(2-hydroxyphenyl)-1-piperazinyl]propoxy}-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one

Rendimiento 54.0%

Disolventes

ethanol

chloroform

acetone

Condiciones de reacción

Procedimiento

Method A (40 h at 50° C.; 4 equivalents of potassium carbonate); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 1-(2-hydroxyphenyl)piperazine dihydrobromide; yield 54%; fusion point 136°-139° C. (from chloroform and ethanol). Fumarate: method E; yield 84%; fusion point 196°-199° C. (from acetone).

Fuente