Reacción #50611

Ecuación de reacción

Fumarate

3-butyl-6-(3-chloropropoxy)-7-methoxy-4-methyl-2H-1-benzopyran-2-one

1-phenylpiperazine

isopropanol

→

3-butyl-7-methoxy-4-methyl-6-[3-(4-phenyl-1-piperazinyl)propoxy]-2H-1-benzopyran-2-one

Rendimiento 72.0%

Disolventes

water

acetone

TBME

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroMethod B (60 h at 50° C.)

Procedimiento

Method B (60 h at 50° C.); starting materials: 3-butyl-6-(3-chloropropoxy)-7-methoxy-4-methyl-2H-1-benzopyran-2-one (example 77) and 1-phenylpiperazine; yield 72%; fusion point 130°-131° C. (from isopropanol and TBME). Fumarate: method E; yield 57%; fusion point 205°-208° C. (from acetone and water).

Fuente