Reacción #50606

Ecuación de reacción

Hydrochloride

6-hydroxy-7-methoxy-3,4-dimethyl-2H-1-benzopyran-2-one

1-[(4-chlorophenyl)methyl]-4-(3-chloropropyl)piperazine

isopropanol

isopropanol

→

6-{3-[4-(4-chlorophenylmethyl)-1-piperazinyl]-propoxy}-7-methoxy-3,4-dimethyl-2H-1-benzopyran-2-one

Rendimiento 74.0%

Disolventes

—

petroleum ether

water

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroMethod D (5 h at 90° C.)

Procedimiento

Method D (5 h at 90° C.); starting materials: 6-hydroxy-7-methoxy-3,4-dimethyl-2H-1-benzopyran-2-one (example 103) and 1-[(4-chlorophenyl)methyl]-4-(3-chloropropyl)piperazine; yield: 74%; fusion point 96°-97° C. (from isopropanol and petroleum ether). Hydrochloride (x 2 HCl): method G; yield 95%; fusion point 255°-260° C. (from isopropanol and water).

Fuente