Reacción #50496

Ecuación de reacción

4-chlorobenzenesulfenylchloride

sodium hydride

1-(2-chloro-5-pyridylmethyl)-2-nitromethyleneimidazolidine

hydrogen

→

1-(2-chloro-5-pyridylmethyl)-2-{(4-chlorophenylthio)nitromethylene}imidazolidine

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas then drop into the solution at 0° C.
2. 2
   workup.STIRRINGAfter stirring for 1 hour at room temperature
3. 3
   FiltraciónThe precipitated crystal was filtered
4. 4
   Otrorecrystalized from ethyl acetate

Procedimiento

0.2 g of sodium hydride 60% in oil was added to a solution of 1.3 g of 1-(2-chloro-5-pyridylmethyl)-2-nitromethyleneimidazolidine in 15 ml of dry dimethylformamide, and the mixture was stirred at room temperature until the generation of hydrogen gas ceased. 0.9 g of 4-chlorobenzenesulfenylchloride was then drop into the solution at 0° C. with stirring. After stirring for 1 hour at room temperature, the reaction mixture was poured into ice water. The precipitated crystal was filtered and recrystalized from ethyl acetate to give 1-(2-chloro-5-pyridylmethyl)-2-{(4-chlorophenylthio)nitromethylene}imidazolidine. The yield was 1.3 g.

Fuente