Reacción #50375

ord-f297ae3acb9542e7bf85a53dda6a37d2

Ecuación de reacción

Cl
hydrochloric acid
[H-].[Na+]
sodium hydride
COC(=O)/C=C/c1ccc(OC)c(O)c1
methyl isoferulate
OCC1CO1
glycidol
→
O=C(O)C=Cc1ccccc1
cinnamic acid

Reactantes

Cl
hydrochloric acid
[H-].[Na+]
sodium hydride
COC(=O)/C=C/c1ccc(OC)c(O)c1
methyl isoferulate
OCC1CO1
glycidol

Reactivos

Ninguno

Disolventes

CS(C)=O
DMSO

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    workup.ADDITIONwas added gradually
  2. 2
    TemperaturaHeating
  3. 3
    TemperaturaThe system was cooled
  4. 4
    Otrowas removed

Procedimiento

3 g of methyl isoferulate was dissolved in 600 ml of DMSO, and 370 mg of sodium hydride was added. The system was heated to 90° C. under N2 gas flow and 7 g of glycidol was added gradually. Heating and agitation was carried out for 0.5 hours. The system was cooled, neutralized by adding hydrochloric acid, solvent was removed and adduct of cinnamic acid and glycerin was obtained.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05426210uspto-grants-1995_06