Reacción #502106

Ecuación de reacción

1H-indazole-3-carboxylic acid

N,O-dimethylhydroxylamine hydrochloride

1-(3-dimethylaminopropyl)-3-ethylcarbodiimide

pyridine

→

compound

Rendimiento 69.1%

N-Methoxy-N-methyl-1H-indazole-3-carboxamide

Rendimiento 69.1%

Disolventes

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe mixture is concentrated
2. 2
   OtroThe yellow precipitate obtained
3. 3
   Lavadois washed with water
4. 4
   Otrodried under reduced pressure

Procedimiento

In a round-bottomed flask, 4.0 g of 1H-indazole-3-carboxylic acid, 2.6 g of N,O-dimethylhydroxylamine hydrochloride, 9.4 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and 8.4 ml of pyridine are placed in 120 ml of tetrahydrofuran. The mixture is stirred at ambient temperature for 20 h. The mixture is concentrated and the residue is taken up in water. The yellow precipitate obtained is washed with water and then dried under reduced pressure. 3.5 g of compound are obtained.

Fuente