Reacción #502102

Ecuación de reacción

[4-[(2-quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol

hydrochloric acid

→

compound

[4-[(2-Quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol hydrochloride

Disolventes

dichloromethane

isopropanol

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONare added to the filtrate
2. 2
   ConcentraciónThe reaction mixture is then concentrated under reduced pressure
3. 3
   FiltraciónThe precipitate is recovered by filtration
4. 4
   Otrooven-dried under reduced pressure

Procedimiento

100 mg of [4-[(2-quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol are suspended in dichloromethane and methanol. The solution is passed through a frit and 5.6 ml of a 0.1N solution of hydrochloric acid in isopropanol are added to the filtrate. The reaction mixture is then concentrated under reduced pressure and the residue is then taken up in diethyl ether. The precipitate is recovered by filtration and oven-dried under reduced pressure. 106 mg of compound are obtained.

Fuente