Reacción #502098

Ecuación de reacción

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylamine

2-bromo-1-(4-chlorophenyl)ethanone

sodium hydrogen carbonate

→

compound

Rendimiento 93.2%

2-(4-Chlorophenyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine

Rendimiento 93.2%

Disolventes

n-propanol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.WAITThe reaction mixture is left
2. 2
   Temperaturato cool
3. 3
   Concentraciónconcentrated under reduced pressure
4. 4
   Otrothe organic phase is then separated
5. 5
   Secadodried over magnesium sulphate
6. 6
   Otrothe solvent is then evaporated off under reduced pressure

Procedimiento

2.5 g of 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylamine and 2.65 g of 2-bromo-1-(4-chlorophenyl)ethanone in 76 ml of n-propanol are placed in a round-bottomed flask. 1.33 g of sodium hydrogen carbonate are added thereto. The mixture is heated at 80° C. for 16 h. The reaction mixture is left to cool and concentrated under reduced pressure. The residue is taken up between water and ethyl acetate, the organic phase is then separated by settling out and dried over magnesium sulphate, and the solvent is then evaporated off under reduced pressure. 3.75 g of compound are obtained.

Fuente