Reacción #501984

Ecuación de reacción

(Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetic acid

methanol

→

(Z)-2-(2-aminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetic acid

Rendimiento 60.8%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe suspension is refluxed for 2 hours
2. 2
   Temperaturawith heating
3. 3
   TemperaturaAfter cooling
4. 4
   Otrocrystalline precipitates
5. 5
   Filtraciónare collected by filtration
6. 6
   Lavadothe crystals are washed with ethyl acetate
7. 7
   OtroThe crystals are recrystallized from a mixture of 500 ml of methanol and 50 ml of water
8. 8
   Otrodried at 70° C. under reduced pressure

Procedimiento

49 g of (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetic acid are suspended in a solution of one liter of methanol containing 40 ml of water, and the suspension is refluxed for 2 hours with heating. After cooling, crystalline precipitates are collected by filtration, and the crystals are washed with ethyl acetate. The crystals are recrystallized from a mixture of 500 ml of methanol and 50 ml of water, and dried at 70° C. under reduced pressure. 15.7 g of (Z)-2-(2-aminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetic acid are obtained as colorless prisms. The physico-chemical properties of this product are identical with those of the product obtained in Example 2-(4).

Fuente