Reacción #50160

Ecuación de reacción

Water

2-ethylimidazole

triethylamine

dimethylsulfamoyl chloride

→

1-dimethylsulfamoyl-2-ethylimidazole

Rendimiento 86.1%

Disolventes

chloroform

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrois separated
2. 2
   Concentraciónconcentrated
3. 3
   workup.DISSOLUTIONThe residue is dissolved in ethyl acetate (1 liter)
4. 4
   Lavadowashed with water
5. 5
   Secadodried over sodium sulfate
6. 6
   Concentraciónconcentrated
7. 7
   workup.DISTILLATIONDistillation

Procedimiento

To a stirred solution of 2-ethylimidazole (100 g) and triethylamine (115 g) in chloroform (800 ml) at 0° C. is added a solution of dimethylsulfamoyl chloride (153 g) in chloroform (200 ml). The mixture is stirred overnight at room temperature. Water (1.5 liter) is added to the reaction mixture after which the organic layer is separated and concentrated. The residue is dissolved in ethyl acetate (1 liter) and washed with water, and then dried over sodium sulfate and concentrated. Distillation gives 1-dimethylsulfamoyl-2-ethylimidazole (182 g) as a colorless liquid.

Fuente