Reacción #501446

Ecuación de reacción

4-trifluoromethylaniline

t-butyl hypochlorite

ethyl 2-(methylthio)acetate

→

5-trifluoromethyl-2-oxindole

Disolventes

triethylamine

Condiciones de reacción

Procedimiento

In analogous fashion, 4-trifluoromethylaniline was reacted with t-butyl hypochlorite, ethyl 2-(methylthio)acetate and triethylamine followed by reduction of the 3-thiomethyl-5-trifluoromethyl-2-oxindole thus obtained with Raney nickel, to give 5-trifluoromethyl-2-oxindole, m.p. 189.5°-190.5° C.

Fuente