Reacción #50137

Ecuación de reacción

compound

methyl 2-n-butyl-3-(2'-methoxycarbonylbiphenyl-4-yl)methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4-carboxylate

acetic anhydride

→

methyl 2-n-butyl-5-acetyl-3-(2'-methoxycarbonylbiphenyl-4-yl)methyl-4,5,6,7-tetrahydroimidazo[4,5-c] pyridine-4-carboxylate

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.DISTILLATIONThe solvent is distilled off
2. 2
   workup.ADDITIONto the resulting residue is added chloroform
3. 3
   Lavadothe mixture is washed
4. 4
   Otrodried
5. 5
   Otroevaporated
6. 6
   Otroto remove the solvent
7. 7
   OtroThe residue is purified by silica gel column chromatography (solvent; chloroform/ethanol=10:1)

Procedimiento

To a mixture of the compound obtained in Example 12 (1.70 g) and pyridine (20 ml) is added acetic anhydride (5 ml), and the mixture is stirred overnight. The solvent is distilled off, and to the resulting residue is added chloroform, and the mixture is washed, dried, and evaporated to remove the solvent. The residue is purified by silica gel column chromatography (solvent; chloroform/ethanol=10:1) to give methyl 2-n-butyl-5-acetyl-3-(2'-methoxycarbonylbiphenyl-4-yl)methyl-4,5,6,7-tetrahydroimidazo[4,5-c] pyridine-4-carboxylate (0.47 g) as an oil. NMR (CDCl3) δ: 0.88 (3H, t), 2.21 (3H, s), 3.46 (3H, s), 3.64 (3H, s), 5.33 (2H, ABq)

Fuente